Compute effective hazard ratio with treatment waning

Returns the effective hazard ratio at a given time on treatment, accounting for waning of treatment effect.

Usage

waning_hr(base_hr, time_on_tx, start, duration, type = "linear")

Arguments

base_hr

Numeric. Initial treatment HR (< 1 means benefit).

time_on_tx

Numeric. Time the patient has been on treatment.

start

Numeric. Time at which waning begins (HR = base_hr before this).

duration

Numeric. Duration of the waning period (HR reaches 1 at start + duration).

type

Character. Waning function: "linear" (default), "exponential", or "instant".

Value

Numeric scalar: effective HR at time_on_tx.